Pancreatic Pseudocyst as a Cause of Gastrointestinal Bleeding and Hemobilia

A case of hemobilia from a pancreatic pseudocyst which developed after cholecystostomy and aspiration of the pseudocyst, intended to relieve biliary obstruction, is discussed. These previously reported cases are briefly reviewed.     

A double-blind, randomized, parallel group study of omeprazole and ranitidine in Korean patients with gastric ulcer

Abstract The efficacy of the proton pump inhibitor omeprazole, 20 mg every morning, was compared with that of the H₂-receptor antagonist ranitidine, 150 mg every morning and at bedtime, in a double-blind randomized parallel group study in 250 patients with gastric or prepyloric uicers. At both 4 and 8 weeks, significantly more patients had healed ulcers in the omeprazole group than the ranitidine group, whether the results were analysed on a per-protocol or an intention-to-treat basis. At 4 weeks, 74% of patients in the omeprazole group were healed compared with 51% in the ranitidine group ( P = 0.001), and at 8 weeks the corresponding values were 99 and 82% ( P = 0.001, per-protocol cohort). Omeprazole treatment and small ulcer size significantly increased the probability of healing, but smoking had no significant effect. Patients in the omeprazole group had significantly fewer occurrences of daytime epigastric pain during the first 4 weeks than the ranitidine group ( P = 0.0037), as shown by their diary cards. Both treatments were well tolerated.     

The clinical values of squamous cell carcinoma antigen and carcinoembryonic antigen in patients with cervical cancer treated with concurrent chemoradiotherapy

The objective of this study was to determine the prognostic significance of the pre- and posttreatment serum levels of the squamous cell carcinoma antigen (SCC-Ag) and carcinoembryonic antigen (CEA). From 2001 to 2005, 211 patients were treated with concurrent chemoradiotherapy (CCRT). The SCC-Ag and CEA levels were measured before treatment, 1 month after treatment, and during the follow-up. The association between the pretreatment tumor marker levels and the clinical prognostic factors was evaluated. The frequency of complete remission (CR) and the normalization of the posttreatment tumor marker were also analyzed. The pretreatment serum levels of CEA and SCC-Ag were elevated in 68 (32.2%) and 148 (70.1%) patients, respectively. The number of patients with an elevated pretreatment SCC-Ag level was associated with the FIGO stage, tumor volume, and pelvic lymph node status. The pretreatment CEA was only significantly related to the tumor volume and pelvic lymph node involvement. One month after completing CCRT, the CEA and SCC-Ag levels were normalized in almost all patients with an incidence of 88.2% (60/68) and 93.2% (138/148), respectively. Among the patients who gained CR with a previously elevated pretreatment CEA and SCC-Ag, the values were normalized in 92.1% (58/63) and 96.4% (134/139) at 1 month, respectively. Combination assays of the pre- and posttreatment serum CEA and SCC-Ag levels appear to be useful for both predicting the prognosis and estimating the clinical response in cervical cancer. However, the routine combined measurement with SCC-Ag of CEA in all patients had limited additional effect in predicting the prognostic significance.     

可摘局部义齿适合性方法的评价

目的: 评价可摘局部义齿(removable partial denture, RPD)适合性的三种方法的异同及适应证。方法: 在下颌牙列缺损石膏模型上制作RPD,用硅橡胶印模材复制RPD与模型表面的间隙形成硅橡胶薄膜样本。在RPD各组件处的薄膜样本上,用硅橡胶膜切片测量法并选择不同数量的测量点测量获得薄膜平均厚度,再用单因素方差分析和独立样本t检验比较基托、大连接体、牙合支托处测量点数量不同对测量结果的影响。采用硅橡胶膜切片测量法、石膏模型三维分析法和翻制模型三维分析法测量RPD各组件处硅橡胶薄膜的厚度,用单因素方差分析比较三种方法的测量结果差异是否有统计学意义。结果: 硅橡胶膜切片测量法选取测量点数量不同测得的基托和大连接体处硅橡胶薄膜的平均厚度差异有统计学意义(P<0.05),牙合支托处硅橡胶薄膜的平均厚度差异无统计学意义(P>0.05)。三种评价方法测得的RPD各组件和总体的硅橡胶薄膜厚度差异均有统计学意义(P<0.01),多重比较表明,石膏模型三维分析法和翻制模型三维分析法的测量结果较硅橡胶膜切片测量法的薄(P<0.05),石膏模型三维分析法和翻制模型三维分析法测量的硅橡胶薄膜厚度差异无统计学意义(P>0.05)。结论: 硅橡胶膜切片测量法的测量结果受测量点数量影响,其测量结果可靠性较差;石膏模型三维分析法、翻制模型三维分析法较硅橡胶膜切片测量法能更全面、有效地评价RPD的适合性,石膏模型三维分析法适用于体外评价,翻制模型三维分析法适用于体内评价。     

Ultrasonographic detection of spontaneous rupture in the Biceps tendon of a patient with rheumatoid arthritis

Ultrasonography is a useful imaging modality for the diagnosis of pathologic conditions in the biceps tendon. We describe a 64‐year old man with rheumatoid arthritis (RA) who suddenly developed a painless lump in the antecubital region of the right arm. The bulging was prominent when he flexed his forearm. Proximal loss of the long head in biceps tendon could be demonstrated by ultrasonography. The ultrasonographic features of spontaneous isolated biceps tendon rupture occurring in a patient with RA are described.     

Impact of Occluded Culprit Arteries on Long‐Term Clinical Outcome in Patients with Non‐ST‐Elevation Myocardial Infarction: 48‐Month Follow‐Up Results in the COREA‐AMI Registry

Background

The prognostic impact of occluded culprit arteries in non‐ST‐elevation myocardial infarction (NSTEMI) patients beyond 12 months has not been investigated.

Objectives

The impact of occluded culprit arteries on a composite of cardiac death (CD), recurrent nonfatal MI (RMI), and target vessel revascularization (TVR) in patients who presented with NSTEMI was investigated during a 48‐month follow‐up using propensity‐score (PS) matching.

Methods

A total of 2,878 NSTEMI patients in the COREA‐AMI (COnvergent REgistry of cAtholic and chonnAm university for Acute MI) Registry were classified according to the angiographic flow of culprit arteries (occlusion [OC], n = 1,070; nonocclusion, n = 1,808). After PS matching, the incidence of the primary end‐point, a composite of CD, RMI, and TVR was compared.

Results

The median follow‐up duration was 47.3 months (IQR 32.7–66.2). In the PS‐matched population, the 48‐month cumulative rates of the primary end‐point (27.5% vs. 17.9%, P < 0.001) and each event were higher in the OC group (CD: 9.0% vs. 5.4%, RMI: 16.3% vs. 9.4%, TVR: 10.5% vs. 5.6%, respectively, P < 0.05). In multivariate Cox regression analysis, occluded culprit arteries showed the significant statistical impact on the primary end‐point (HR 1.689 [1.385–2.059], P < 0.001) and each event (CD: 1.736 [1.218–2.475], RMI: 1.918 [1.468–2.505], TVR: 2.042 [1.453–2.869], respectively, P < 0.05). Furthermore, in the 12‐month landmark analysis, occluded culprit arteries were still associated with higher risk of primary end‐point beyond 12 months (P < 0.001).

Conclusions

Occluded culprit arteries were independently associated with the higher risk of CD, RMI, and TVR in NSTEMI patients during the 48‐month follow‐up. (J Interven Cardiol 2014;27:12–20)

     

Progress in Chimeric Vector and Chimeric Gene Based Cardiovascular Gene Therapy

Gene therapy 15 to deliver and exPress a protee-tive exo罗nous罗ne into the somatie eells Of a pa-tient in order to eorreet a defeetive gene.It rePre-sents a new way to treat human diseases.Cardiovas-eular disease 15 the leading eause of death in theworld一wide.Gene theraPy for eardiovascular diseasesas a novel approaeh 15 being developed.A key stepof gene therapy 15 to transfer genes.New veetors,novel target genes identified·and ex详rimental models(e·9.,ehronie isehemie model,animal model…     

Kale Juice Improves Coronary Artery Disease Risk Factors in Hypercjlolesterolemiic Men

Objective To evaluate the effect of 3-month kale(Brassica oleracea acephala)iuice supplementation on coronary artery disease risk factors among hypercholesterolemic men.Methods Thkty-two men with hypercholesterolemia (>200 mg/dL)were recruited after annual health examinations among the faculty and staff at university.The subijects consumed 150 mL of kale iuice per day for a 12-week intervention period.Dietary and anthropomeu-ic assessments were performed and blood samples were collected to evaluate biochemical profdes before and after supplementation.Results Serum concentrations of HDL-cholesterol,and HDL-to LDL-cholesterol ratio were significantly increased by 27%(P<0.0001)and 52%(P<0.0001),respectively.The LDL-cholesterol concentration and the atherogenic index were significantly reduced by 1O%(P=0.O007)and 24.2%(P<0.0001),respectively without affecting body mass index,waist and hip circumferences,or nutrient intakes after three months of supplementation.While there was no difference in the concentration of malondialdehvde,significant increase in glutathione peroxidase activity(P=0.0005)were accompanied by a significant increase in the serom selenium level(P=0.0132).It was also foand that the responses of these risk factors to kale inice administration were dependent on smoking status.Conelusion Regular meals supplementation with kale juice can favorably influence serum lipid profiles and antioxidant systems.and hence contribute to reduce the risks of coronary artery disease in male subjects with hyperlipidemia.     

朝文版社区痴呆筛查工具的信度和效度评价

目的 朝文版检测社区痴呆筛查工具(CSID-K)的信度与效度.方法 以韩国社区65岁以上老年人为对象,选择痴呆组(实验组)以及抑郁症组、有文化的健康组、无文化的健康组(对照组)各30名,了解CSID-K评分情况以及他们的社会人口学特征、抑郁症的严重程度、认知功能.结果 CSID-K的认知分(COGSCORE)和扶养者分(RELSCORE)的半分信度、内部一致性信度、评定者之间一致性信度、重测信度分别为0.82,0.87,0.75,0.72和0.85,0.88,0.83,0.79,均优秀(P<0.01).实验组的COGSCORE、RELSCORE、识别功能分(DFSCORE)与简易精神状况检查之间的相关系数分别为0.90,-0.48,-0.76,与老年精神状态进度表B3器质性部分分数之间的相关系数分别为-0.76,0.34,0.60.实验组的COGSCORE、RELSCORE、DFSCORE分别为(21.3±3.1)分、(6.4±4.9)分、(0.3±0.2)分,与抑郁症组的(28.1±2.2)分、(4.0±1.9)分、(0.1±0.063)分和有文化组的(29.2±1.6)分、(2.5±2.1)分、(0.041±0.069)分以及无文化组的(27.7±1.8)分、(3.2±2.8)分、(0.086±0.096)分相比,均差异有显著性(P<0.05).结论 CSID-K能够可靠和有效地筛查出韩社区老年人中的痴呆,同时可用于l临床实际,也可用于跨文化研究.